The journal of nutrition, health & aging (2022) https://doi.org/10.1007/s12603-022-1758-z
L. J. Strath, L. Meng, A. Rani, P. Sinha, A. J. Johnson, Z. Huo, T. C. Foster, J. D. Edburg, R. B. Fillingim & Yenisel Cruz-Almeida
Objectives
To examine the relationship between Vitamin D status and pain intensity and disability in individuals with and without knee pain, and to examine the role of epigenetics in this relationship.
Design
Cross-sectional analysis of data from the UPLOAD-2 study (Understanding Pain and Limitations in OsteoArthritic Disease-2).
Participants
189 individuals aged 45–65 years and older.
Measurements
Serum Vitamin D levels, pain related interference and characteristic pain intensity measures, and the epigenetic clock GrimAge derived from blood analyses.
Results
Lower Vitamin D was associated with advanced epigenetic aging (AgeAccelGrim), greater pain and disability and that (AgeAccelGrim) mediated the relationship between Vitamin D status and self-reported pain (ab = -0.0799; CI [-0.1492, -0.0237]) and disability (ab = -0.0669; CI [-0.1365, -0.0149]) outcomes.
Conclusion
These data support the notion that lifestyle factors such as nutrition status play a key role in aging process, as well as the development and maintenance of age-related diseases such as pain. Modifying nutrition status could help promote healthy aging and reduce pain.
Download the PDF from VitaminDWiki
VitaminDWiki - Osteoarthritis pages with KNEE in title (29 as of March 2022)
This list is automatically updated
Items found: 32
|
Title |
|
Modified |
|
ACL Knee surgery increases risk of subsequent Knee Osteoarthritis by up to 2X (both low D) – Sept 2024 |
|
19 Sep, 2024 |
|
Total knee arthroplasty – worse outcome if low vitamin D – many studies |
|
05 Apr, 2024 |
|
Knee osteoarthritis treated by Vitamin D - many studies |
|
13 Dec, 2023 |
|
Knee Osteoarthritis treated by vitamin D if use more than 2,000 IU daily or non-daily high dose – meta-analysis Aug 2023 |
|
21 Aug, 2023 |
|
Ageing faster and more knee pain are associated with low vitamin D – March 2022 |
|
08 Mar, 2022 |
|
I needed more than Vitamin D to treat my knee osteoarthritis |
|
06 Nov, 2021 |
|
Knee osteoarthritis helped by Low Level Laser Therapy |
|
02 Nov, 2020 |
|
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020 |
|
21 Oct, 2020 |
|
Less Knee Osteoarthritis if take more Vitamin D – 8 MRI confirmations – Nov 2018 |
|
10 Oct, 2018 |
|
Knee Osteoarthritis benefited by 20 ng of Vitamin D for 5 years – RCT July 2018 |
|
10 Jul, 2018 |
|
If You Tear a Knee Ligament, Arthritis Is Likely to Follow in 10 Years (both are related to low Vitamin D) – Nov 2017 |
|
08 Nov, 2017 |
|
More pain after knee surgery if low vitamin D – Oct 2015 |
|
26 Aug, 2017 |
|
Knee osteoarthritis helped by vitamin D2 (40,000 IU weekly raised 57 % above 30 ng) June 2017 |
|
29 Jul, 2017 |
|
Knee Osteoarthritis (Radiographic ) 3X less if have lots of Magnesium – May 2015 |
|
29 Jul, 2017 |
|
Reduced knee osteoarthritis if consistently supplement with vitamin D for 2 years – April 2017 |
|
29 Jul, 2017 |
|
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 |
|
20 Jul, 2017 |
|
Knee osteoarthritis not helped by Vitamin D (when you ignore vitamin D levels) – April 2017 |
|
25 Apr, 2017 |
|
Knee osteoarthritis strongly associated with low Boron – 2015 |
|
24 Mar, 2017 |
|
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 |
|
24 Dec, 2016 |
|
Synovitis (knee osteoarthritis) associated with low vitamin D – Dec 2016 |
|
21 Dec, 2016 |
|
Vitamin D increasing muscle strength may reduce knee pain – Feb 2016 |
|
22 Nov, 2016 |
|
Hypothesis- Knee osteoarthritis is reduced by vitamin D increasing level of nitric oxide – Dec 2013 |
|
06 Oct, 2016 |
|
Good evidence for knee osteoarthritis and vitamin D, unsure of other OA – Review March 2013 |
|
06 Oct, 2016 |
|
Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015 |
|
08 Mar, 2016 |
|
Knee pain in seniors predicted by low vitamin D 5 years before – Feb 2014 |
|
27 Oct, 2015 |
|
Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015 |
|
03 Oct, 2015 |
|
Will knee osteoarthritis be prevented with 1700 IU of vitamin D – proposed RCT |
|
08 Aug, 2015 |
|
Knee osteoarthritis more painful if low vitamin D, especially among obese – Jan 2015 |
|
12 Apr, 2015 |
|
Knee Osteoarthritis 3.2X more likely to get worse if low Vitamin D and high PTH – Dec 2014 |
|
23 Feb, 2015 |
|
Knee osteoarthritis 2.3 X more likely to get worse if low level of vitamin D – Dec 2014 |
|
07 Oct, 2014 |
|
Probability of knee osteoarthritis up 50 percent if 20 ng less vitamin D – Nov 2011 |
|
10 Nov, 2012 |
|
Knee osteoarthritis associated with low vitamin D for those under age 55 – Dec 2010 |
|
10 Nov, 2012 |
VitaminDWiki pages with EPIGENETICS in title
This list is automatically updated
Items found: 20
|
Title |
|
Modified |
|
Skin problems and Osteoporosis may be related via Vitamin D, Microbiota, and Epigenetics - Dec 2024 |
|
12 Jan, 2025 |
|
Vitamins etc, appear to slow down epigenetic aging and reduce inflammation – March 2024 |
|
26 Mar, 2024 |
|
Epigenetics and Vitamin D – many studies |
|
23 Oct, 2023 |
|
Vitamin D Health problems can run in families (epigenetics, they miss other reasons) – June 2023) |
|
16 Jun, 2023 |
|
Vitamin D supplementation is associated with slower epigenetic aging - May 2022 |
|
21 Jun, 2022 |
|
Epigenetics, vitamin D, and Multiple Sclerosis |
|
15 Jun, 2022 |
|
Epigenetics - PDFs and links, with and without Vitamin D |
|
25 Feb, 2021 |
|
Epigenetics identified Cervical Cancer 100 percent of time – 2019 |
|
23 Dec, 2019 |
|
Stressors as a fetus or child can cause health problems in adult (perhaps via epigenetics) – Dec 2017 |
|
14 Oct, 2018 |
|
Health problems can persist through many generations – Epigenetics and Vitamin D |
|
13 Oct, 2018 |
|
Epigenetics meets endocrinology – 2011 |
|
13 Oct, 2018 |
|
Vitamin D Receptor – environment, genetics and epigenetics – May 2015 |
|
13 Oct, 2018 |
|
Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016 |
|
05 May, 2016 |
|
Epigenetics of Multiple Sclerosis – March 2014 |
|
06 Sep, 2015 |
|
Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss - June 2015 |
|
22 Jun, 2015 |
|
Epigenetics meets endocrinology - 2011 |
|
21 Jan, 2015 |
|
Hypothesis: Epigenetics, vitamin D, and Multiple Sclerosis – Nov 2012 |
|
29 Aug, 2014 |
|
Epigenetics of prostate cancer and vitamin D – June 2010 |
|
09 Jul, 2013 |
|
Lung disease, vitamin D, and epigenetics – Aug 2011 |
|
13 Feb, 2012 |
|
Epigenetics and vitamin D – June 2010 clips from the web |
|
05 Jun, 2010 |
VitaminDWiki pages - Meta-analysis and Pain